By George M. Rodgers
This finished quantity discusses the protease ADAMTS13, summarizing the present prestige of easy and medical examine. The 9 authoritative chapters start with a ancient viewpoint through exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its basic functionality in hemostasis (cleavage of von Willebrand factor). rising study subject matters for ADAMTS13 are lined, together with its capability position in angiogenesis and different points of mobile biology. extra subject matters comprise laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and purchased ADAMTS13 deficiency. A bankruptcy on comparable thrombotic microangiopathic (TMA) problems examines the variations among TMAs linked to ADAMTS13 deficiency and people now not linked to ADAMTS13 deficiency. a last bankruptcy reports the initial info on rising points of ADAMTS13, reminiscent of the prestige of recombinant ADAMTS13 items and their power utility.
Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and ailment is an important source for medical hematologists, transfusion medication physicians, and researchers attracted to hemostasis, vascular biology, biochemistry, and metalloproteases.
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