Endothelin in Renal Physiology and Disease (Contributions to by M. Barton,D.E. Kohan

By M. Barton,D.E. Kohan

Endothelin is a 21-amino acid peptide that exerts uniquely effective and long-lasting results at the kidney, together with rules of water and electrolyte excretion, blood strain, cellphone development, irritation and fibrosis. in past times 10 years, the sector has advanced speedily; we're now uncovering the capability significance of endothelin receptor antagonists (ERAs) within the remedy of kidney disease.This booklet studies experimental techniques, preclinical reports and medical facts which shape the foundation of our present figuring out of the organization among endothelin and kidney disorder. Acclaimed specialists in pharmacology, molecular biology, body structure, cardiovascular medication, and nephrology have contributed well timed stories facing renal pharmacology and body structure of endothelin, the function of endothelin in renal illness improvement and ERAs in preclinical reports, and the present country of medical improvement of period treatment in renal medicine.The book handy can be a precious reference resource for nephrologists, internists and different healthcare pros, renal physiologists and molecular biologists, post-doctoral researchers and scholars within the existence sciences, in addition to for scientists and determination makers in drug examine and development.

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