Lymphocytes, Macrophages, and Cancer (Recent Results in by G. Mathe,I. Florentin,M.-C. Simmler

By G. Mathe,I. Florentin,M.-C. Simmler

clean dwelling Bacillus Calmette-Guerin (BeG), injected i.v. into (C57BI/ 6xDBA/2)FI mice, activated peritoneal macrophages rendering them hugely cytotoxic for tumor cells in vitro. This cytotoxic job w~s already maximal 14 days after injection of one mg of BCG and remained sturdy while three or five mg of BCG got. while spleen cells of the BCG-treat~d mice confirmed strongly depressed responses to the T-cell mitogens,PHA and Con A, regardless of the dose of BCG injected. The inhibitory impact used to be proven to be mediated by means of suppressor cells which had features of macrophages given that they can be got rid of by means of carbonyl iron and magnet remedy and have been adherent to plastic. unlike it was once saw after injec­ tion of one mg of BCG, those suppressor cells by myself didn't account for the melancholy of T-cell re.sponses prompted by way of better doses of BCG. Nylon-nonadherent mobilephone populations got from spleen cells handled with three or five mg BCG in part retained the inhibitory job suggesting that suppressor T cells have been additionally brought about after injection of excessive doses of BCG. against this, the responses to the B-cell mitogen LPS of unfractionated and macrophage-depleted spleen cells weren't affected or considerably superior reckoning on the dose of BCG injected.

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